WHAT ARE SARMs?

Initially developed for medical applications

Selective Androgen Receptor Modulators (SARMS).

Originally, these compounds were studied and developed for potential medical applications, particularly for the prevention of muscle wasting caused by various diseases such as cancer, hypogonadism, and osteoporosis.

Due to its limited androgenic properties, animal studies would allow gaining muscle mass, with fewer side effects associated with steroids.

In medical applications, when administered in the recommended doses, these products can help prevent muscle loss in cancer patients (always under medical prescription).

Although SARMS share things in common, each one is different.

This website guarantees the compounds by the analyzes carried out in prestigious laboratories outside of Daisanlabs with a purity between 98% and 100%.

On several occasions, products from suppliers have been discarded that after being analyzed were not true sarms

DO THEY HAVE SIDE EFFECTS?

In animals, studies have reported that side effects at low doses are usually null or very low and when they appeared, stopping supplying the product for 15 days returned to normal levels.

All this depended on the amount of dose supplied and the time of administration to the animals.

Animal studies of all the products on this website reported that, being substances that bind to the androgen receptor, they cause inhibition of the hormonal axis, create liver toxicity and alter the lipid profile, to a greater or lesser extent, with the exception of mk- 677 and gw-501516 that did not cause any of these side effects.

SCIENTIFIC STUDIES CARRIED OUT ON SARMS

Choi, S. M., & Lee, B. M. (2015). Comparative safety evaluation of selective androgen receptor modulators and anabolic androgenic steroids. Expert Opinion on Drug Safety, 14(11), 1773-1785.
George, S., Petit, G. H., Gouras, G. K., Brundin, P., & Olsson, R. (2013). Nonsteroidal selective androgen receptor modulators and selective estrogen receptor β agonists moderate cognitive deficits and amyloid-β levels in a mouse model of Alzheimer’s disease. ACS chemical neuroscience, 4(12), 1537-1548.
Ramaraj, P., Artaza, J. N., Sinha-Hikim, I., & Taylor, W. E. (2015). Effect of Androstenedione on Adipogenesis in Murine C3H10T1/2 Mesenchymal Cells. Open Journal of Endocrine and Metabolic Diseases, 5(02), 9.
Wang, X., Smith, G. I., Patterson, B. W., Reeds, D. N., Kampelman, J., Magkos, F., & Mittendorfer, B. (2012). Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women. American Journal of Physiology-Endocrinology and Metabolism, 302(6), E740-E746.
Bhasin, S., Storer, T. W., Berman, N., Callegari, C., Clevenger, B., Phillips, J. & Casaburi, R. (1996). The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. New England Journal of Medicine, 335(1), 1-7.
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Bhasin, D., Berman, N. & Dzekov, J. (2001). Testosterone dose-response relationships in healthy young men. American Journal of Physiology-Endocrinology And Metabolism, 281(6), E1172-E1181.
Casaburi, R., Bhasin, S., Cosentino, L., Porszasz, J., Somfay, A., Lewis, M. I. & Storer, T. W. (2004). Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 170(8), 870-878.
Johansen, K. L., Mulligan, K., & Schambelan, M. (1999). Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. Jama, 281(14), 1275-1281.
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M. & Magliano, L. (2005). Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. The Journal of Clinical Endocrinology & Metabolism, 90(2), 678-688.
Woodhouse, L. J., Reisz-Porszasz, S., Javanbakht, M., Storer, T. W., Lee, M., Zerounian, H., & Bhasin, S. (2003). Development of models to predict anabolic response to testosterone administration in healthy young men. American Journal of Physiology-Endocrinology and Metabolism, 284(5), E1009-E1017..
Storer, T. W., Magliano, L., Woodhouse, L., Lee, M. L., Dzekov, C., Dzekov, J. & Bhasin, S. (2003). Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. The Journal of Clinical Endocrinology & Metabolism, 88(4), 1478-1485.
Calof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005). Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 60(11), 1451-1457.
Bhasin, S., & Jasuja, R. (2009). Selective androgen receptor modulators (SARMs) as function promoting therapies. Current opinion in clinical nutrition and metabolic care, 12(3), 232.
Srinath, R., & Dobs, A. (2014). Enobosarm (GTx-024, S-22): a potential treatment for cachexia. Future Oncology, 10(2), 187-194.
Basaria, S., Collins, L., Dillon, E. L., Orwoll, K., Storer, T. W., Miciek, R., … & Gordon, G. (2013). The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(1), 87-95.
Marcantonio, E. E., Witter, R. E., Ding, Y., Xu, Y., Klappenbach, J., Wang, Y., & Stoch, S. A. (2010). A 12-Week Pharmacokinetic and Pharmacodynamic Study of Two Selective Androgen Receptor Modulators (SARMs) in Postmenopausal Subjects. Endocrine Reviews Supplement, 31 (1), 872.
Papanicolaou, D. A., Ather, S. N., Zhu, H., Zhou, Y., Lutkiewicz, J., Scott, B. B., & Chandler, J. (2013). A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia. The journal of nutrition, health & aging, 17(6), 533-543.
Srinath, R., & Dobs, A. (2014). Enobosarm (GTx-024, S-22): a potential treatment for cachexia. Future Oncology, 10(2), 187-194.
Dalton, J. T., Taylor, R. P., Mohler, M. L., & Steiner, M. S. (2013). Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. Current opinion in supportive and palliative care, 7(4), 345-351.
Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., & Steiner, M. S. (2011). The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial. Journal of cachexia, sarcopenia and muscle, 2(3), 153-161.
Basaria, S., Collins, L., Dillon, E. L., Orwoll, K., Storer, T. W., Miciek, R., . & Gordon, G. (2013). The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 68(1), 87-95.